The Science Behind Nitric Oxide & Nasal Hygiene

A Nobel Prize - Recognized Discovery

Nitric Oxide (NO) has been studied for decades as an important biological signaling molecule. In 1992, the journal Science named Nitric Oxide “Molecule of the Year”1, highlighting its significance across multiple areas of biology. In 1998, the Nobel Prize in Physiology or Medicine was awarded for discoveries related to nitric oxide signaling in the human body2.

Since then, nitric oxide has been widely researched for its role in normal physiological processes, including those occurring in the nasal and respiratory system3.

Science, Simplified

Bridging biological discovery with daily hygiene.

Nitric Oxide is a naturally occurring molecule studied for decades

Recognized by Science and the Nobel Prize for its biological role

Produced naturally in the nasal passages

Widely researched for signaling and nasal physiology

NOWONDER™ applies this science to daily nasal hygiene, not medical treatment

Designed for cleanliness, comfort, and everyday use.

Nitric Oxide in the Nasal Environment

Nitric Oxide is naturally produced in the paranasal sinuses4 and forms part of the complex system that supports normal nasal function.

Scientific research has explored several ways nitric oxide participates in nasal physiology:

Molecular Interaction

Laboratory and academic studies have examined how nitric oxide behaves at a molecular level, including how it interacts with microorganisms and environmental particles under controlled research conditions5. These findings have contributed to broader scientific understanding of nitric oxide’s chemical and reactive properties.

Support of Natural Clearance Mechanisms

The nasal passages are lined with cilia — microscopic hair-like structures responsible for moving mucus and trapped particles out of the nose6. Research has investigated how nitric oxide signaling relates to normal ciliary activity as part of healthy nasal physiology7.

Biological Signaling

Nitric oxide acts as a signaling molecule, allowing cells to communicate and respond to changes in their environment8. This signaling role is one reason nitric oxide continues to be a subject of ongoing scientific interest across physiology, molecular biology, and respiratory research.

What the Research Shows

A growing body of peer-reviewed literature has explored nitric oxide biology across multiple scientific fields, including respiratory physiology, molecular biology, and hygiene-related research.

These studies focus on:

  • The chemical behavior of nitric oxide molecules9
  • Their role in normal nasal and respiratory physiology10
  • How nitric oxide participates in biological signaling pathways11

Importantly, this research examines nitric oxide as a biological molecule, not consumer or retail products.

From Research to Daily Nasal Hygiene

Inspired by decades of nitric oxide research, NOWONDER™ Nasal Cleanser is designed as a non-medicated nasal hygiene product. Its purpose is to gently cleanse and refresh the nasal passages as part of an everyday personal care routine.

NOWONDER™ is not intended to replace medical treatment or alter the body’s immune response. It is designed for regular hygiene use, similar to other daily personal care products.

The BuyEnov Experience

Over the past four years, BuyEnov has delivered more than 70,000 orders worldwide, helping customers incorporate modern nasal hygiene into their daily routines with reliable service, transparent policies, and global shipping.

Research Disclosure

This page provides educational information about nitric oxide biology based on publicly available, peer-reviewed scientific research. NOWONDER™ Nasal Cleanser is a hygiene product, not a drug, and is not intended to diagnose, treat, cure, or prevent any disease.

References

  1. Culotta, E., & Koshland, D. E. (1992). Nitric oxide: Molecule of the Year. Science, 258(5090), 1862–1865. ↑
  2. Nobel Assembly at Karolinska Institutet. (1998). The Nobel Prize in Physiology or Medicine 1998 – Nitric Oxide as a Signalling Molecule in the Cardiovascular System. ↑
  3. Lundberg, J. O., & Weitzberg, E. (1999). Nasal nitric oxide in man. Thorax, 54(10), 947–952. ↑
  4. Lundberg, J. O., et al. (1995). High nitric oxide production in human paranasal sinuses. Nature Medicine, 1, 370–373. ↑
  5. Fang, F. C. (1997). Perspectives series: Host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. Journal of Clinical Investigation, 99(12), 2818–2825. ↑
  6. Wanner, A., Salathé, M., & O’Riordan, T. G. (1996). Mucociliary clearance in the airways. American Journal of Respiratory and Critical Care Medicine, 154(6), 1868–1902. ↑
  7. Jain, B., et al. (2010). Nitric oxide regulation of ciliary beat frequency. Respiratory Physiology & Neurobiology, 173(2), 110–115. ↑
  8. Moncada, S., Palmer, R. M. J., & Higgs, E. A. (1991). Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacological Reviews, 43(2), 109–142. ↑
  9. Ignarro, L. J. (2000). Nitric oxide biology and pathobiology. Academic Press. ↑
  10. Weitzberg, E., & Lundberg, J. O. (2002). Humming greatly increases nasal nitric oxide. American Journal of Respiratory and Critical Care Medicine, 166(2), 144–145. ↑
  11. Bogdan, C. (2001). Nitric oxide and the immune response. Nature Immunology, 2, 907–916. ↑